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. Author manuscript; available in PMC: 2015 Nov 1.
Published in final edited form as: Nat Cell Biol. 2015 Apr 27;17(5):615–626. doi: 10.1038/ncb3160

Figure 3.

Figure 3

MPC enhancers are enriched in DNA binding motifs for TEAD and known pancreatic transcription factors. (a) TEAD recognition motifs were strongly enriched in a de novo motif search in MPC enhancers. Other enriched matrices match binding sites of known pancreatic regulators. See Supplementary Tables 10 and 11 for a complete list of motifs enriched in MPC and MPC-selective enhancers, respectively. (b) TEAD motifs are highly enriched at genomic regions bound by FOXA2 in both in vivo and in vitro MPCs, but not at regions bound by FOXA2 in islets or liver. Binomial distribution P values were obtained using HOMER44. NS: non-significant. (c) Combinations of recognition motifs for TEAD and other pancreatic regulators are specifically enriched in pancreatic MPC enhancers. We searched for combinations of 3 sequence motifs that were contained within 500 bp and were most enriched in pancreatic MPC enhancers relative to 8 other tissue enhancers. The top 50 most enriched motif combinations are shown in Supplementary Table 12.