Table 1. LOPAC hits CRC.
The most active compounds are displayed including unique identifiers (Sigma ID) which are directly purchasable from Sigma Aldrich. All EC50 values shown are in molar (M) concentration. Averaged Max % response and SD max % response are derived from triplicate data for a concentration in which the values are achieving the greatest agonist activity in this assay. The Hill Slope and the description of the biological function of each compound are shown.
| Sigma ID | Final EC50 (M) |
Averaged Max % Response |
SD Max % Response |
Hill Slope | Description |
|---|---|---|---|---|---|
| C 1112 | 223.5E-9 | 107.68 | 8.12 | 1.73 | Cannabinoid receptor agonist |
| P 8887 | 330.7E-9 | 148.76 | 4.26 | 0.28 | Positive allosteric modulator of GABA-A chloride channels |
| U 5882 | 393.4E-9 | 109.46 | 1.84 | 1.79 | Free radical lipid peroxidation inhibitor |
| P 0130 | 832.9E-9 | 121.57 | 6.39 | 1.07 | Suppresses ovulation; induces maturation and secretory activity of the uterine endothelium |