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Evolution of genetic, demographic and clinical correlations of Crohn’s disease through the study period
| Period | Any CARD15 mutation | M:F ratio | Mean age (yr) | CD:UC ratio, cumulative | CD:UC ratio, b region of Ioannina | CD:UC ratio, region of Corfu | Perianal |
| Pre-1994 | 46.10% | 1.4 | 30.4 | 0.23 | 0.26 | 0.2 | 13.80% |
| 1995-1999 | 61.90% | 3.4 | 35.4 | 0.32 | 0.46 | 0.3 | 27.20% |
| 2000-2005 | 46.90% | 1.55 | 33.1 | 0.61 | > 1 | 0.5 | 31.30% |
| Total | 51% | 1.83 | 32.8 | 0.36 | 0.38 | 0.32 | 25.50% |
