Table 3.
CARD15 variant allele frequencies
|
Genotype |
Mutant allele frequency (%) | P; OR (95% CI) | |||
| Samples | -/- | -/+ | +/+ | ||
| R702W | |||||
| CD | 85 | 8 | 3 | 7.29 | 0.015; 3.85 (1.24-11.93) |
| UC | 171 | 9 | 0 | 2.5 | 0.78; 1.26 (0.38-4.13) |
| Control | 96 | 4 | 0 | 2 | |
| G908R | |||||
| CD | 83 | 13 | 0 | 6.77 | 0.70; 0.83 (0.39-1.78) |
| UC | 156 | 24 | 0 | 6.66 | 0.61; 0.82 (0.42-1.58) |
| Control | 84 | 16 | 0 | 8 | |
| Leu1007fsincC | |||||
| CD | 52 | 36 | 8 | 27.08 | < 0.0001; 7.06 (3.46-14.37) |
| UC | 166 | 9 | 5 | 5.27 | 1; 1.06 (0.48-2.32) |
| Control | 90 | 10 | 0 | 5 | |
-/-, homozygous wild-type; -/+, heterozygous; +/+, homozygous mutant. CD: Crohn’s disease; UC: Ulcerative colitis; OR: Odds Ratio; CI: Confidence Interval. The CARD15 gene variants determined in 96 CD patients (from 102 living CD patients out of 105, from our cohort 6 refused genetic test), 180 out of 300 living UC patients and 100 randomly chosen healthy blood donors.