Fig. 2.
Increased S6K1 activity in the mPFC, but not dorsal striatum, produces antidepressant behavior. (A) Representative viral expression in the mPFC of rats (5× and 10×). (B and C) S6K1CA decreased immobility time in the forced swim test (t16 = 3.9, **P < 0.01; time x virus interaction, F2,32 = 7.7, **P < 0.01; n = 8–10). (D) S6K1CA did not alter locomotor activity (t18 = 0.6, P = 0.5744; n = 9–11). (E) Representative viral expression in the dorsal striatum (5×). (F) Infusions of S6K1CA into the dorsal striatum had no effect on immobility time in the forced swim test (t10 = 0.3, P = 0.7531; n = 6). (G) S6K1CA did not affect locomotor activity when infused in the dorsal striatum (t10 = 0.9, P = 0.3848; n = 6). Error bars represent mean ± SEM.