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Decreased S6K1 activity in the mPFC produces prodepressive behavior. (A) Virus was infused into the mPFC. (B and C) S6K1KI increased immobility time in the forced swim test (t14 = 2.2, *P < 0.05; time × virus interaction, F2,28 = 1.0, P = 0.3660; n = 8). (D) S6K1KI did not alter locomotor activity (t14 = 0.6, P = 0.5842; n = 8). Error bars represent mean ± SEM.
