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Suppression of S6K1 activity in the mPFC blocks the antidepressant effects of ketamine. (A) S6K1KI expression in the mPFC increases immobility time in the forced swim test (t26 = 4.8, ***P < 0.0001). (B) Decreased immobility produced by ketamine is blocked by S6K1KI expression (virus x drug interaction, F1,27 = 4.3, *P < 0.05). Error bars represent mean ± SEM. *P < 0.05 compared with CTL/vehicle.
