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S6K1 activity in the mPFC modulates responses to chronic stress. (A) S6K1CA expression in the mPFC produces resilience to chronic stress in the sucrose preference test (stress x virus interaction, F1,26 = 6.1, *P < 0.05; n = 7–8). (B) S6K1KI expression in the mPFC produces anhedonia in the absence of chronic stress (t27 = 2.1, *P < 0.05; n = 14–15). Error bars represent mean ± SEM.
