Skip to main content
. 2015 Apr 27;112(19):E2487–E2496. doi: 10.1073/pnas.1422445112

Fig. 1.

Fig. 1.

IL-33 and IL1RL1 expression in human CRC. (A) qPCR analysis of IL33 expression in adjacent normal mucosa (Norm), adenocarcinoma (Ad), and cell lines derived from adenocarcinomas (Cell line). Data plotted relative to norm ± SEM (n = 20–25). (B) IL33 expression in human whole mucosa or tumor tissue biopsies and laser-microdissected mucosa and crypt epithelium. Ad, colon adenoma or adenocarcinoma; Car, colon carcinoma; Norm, adjacent normal tissue. Data obtained from the Skrzypczak and Skrzypczak 2 colorectal oncomine datasets. Bars indicate the mean. †P ≤ 0.01; ‡P ≤ 0.001; #P ≤ 0.0001. (C–E) Immunohistochemistry for IL-33 in normal adjacent mucosa, adenoma, and carcinoma. Insets show endothelial cells associated with vessels. Arrows indicate IL-33–positive epithelium; arrowheads indicate IL-33–positive endothelial cells. (F–H) Immunohistochemistry for IL1RL1 in normal adjacent mucosa (Normal), adenoma, and carcinoma. Insets show endothelial cells associated with vessels. Arrows indicate IL1RL1-positive epithelium; dashed arrows indicate stromal cells. (Scale bars, 50 μm.)