Table 1.

Schedule of measurements and activities by visit for the PACE study

	Baseline visit	Follow-up (FU) Visits and Telephone (T) Contacts
	EV	BV	T4	T6	T8	FU12	T16	T18	T20	FU24	Up to FU48
Interviewer/Questionnaires §
Informed consent	●
Contact information	●			●		●		●		●	●
Sociodemographic	●
Education and employment		●				●				●	●
Vascular access		●				●				●	●
Residual kidney function		●				●				●	●
Dialysis prescription		●				●				●	●
Dialysis adherence		●				●				●	●
Pre-dialysis education		●				●				●	●
Medical history	●			●		●		●		●	●
Family history of CVD, SCD	●
Female reproductive history		●				●				●	●
Health, behaviour, social history	●					●				●	●
Access to transplant	●					●				●	●
KDQOL-36		●				●				●	●
Symptomatic CVD (Rose, KCQ)		●				●				●	●
Physical activity		●				●				●	●
Dietary questions & 24-hr recall		●	●		●	●	●		●	●	●
Literacy (WRAT4)		●
Cognition (Trails A&B, 3MS)		●				●				●	●
Depression (PHQ9)		●				●				●	●
Oral medications		●				●				●	●
Examination
Height, weight, BMI, WHR		●				●				●	●
Blood pressures		●				●				●	●
Detailed amputation evaluation		●				●				●	●
Frailty assessment		●				●				●	●
Procedures
CT calcium and angiography		●
Echocardiography		●
Pulse wave velocity		●				●				●	●
12 lead & signal averaged ECG		●				●				●	●
4 Limb ankle brachial		●				●				●	●
Blood tests (fasting)
Ionized calcium, magnesium		●				●				●	●
Repository (DNA, RNA, blood, nails)		●				●				●	●
Clinical
Baseline charlson co-morbidity	●
CMS-2728 medical evidence	●
Hospitalizations	Throughout the entire study period
CMS-2746 death notification‡	Collect as needed
Dialysis routine bloods (monthly)	Throughout the entire study period
Glucose, albumin
Complete blood count
Electrolytes (Na, K, Mg, CO2, Ca, Phos)*
Intact PTH*
Fe, TIBC, Ferritin, Aluminum*
URR, spKt/V, nPCR*
Dialysis treatments (weekly) ‡‡	Throughout the entire study period
Dry weight
Dialysis bath (Ca, K, HCO3)*
Prescription (duration, frequency, dialyzer)
Pre and post weights
Pre and post blood pressures (BP)
Dialysis flow rate
Blood flow rate
Intravenous medications

^§KCQ = Kansas City Questionnaire; KDQOL-36 = Kidney Disease Quality of Life 36 Item Instrument; WRAT4 = Wide Range Achievement Test 4^th Edition; Trails A&B; 3MS = Modified Mini-Mental Status Exam; PHQ9 = Patient Health Questionnaire 9; ¶BMI = Body Mass Index; WHR = Waist Hip Ratio; Blood Pressure is collected as 3 seated Blood Pressures; ‡Collected as needed; *Na- sodium K- potassium; Ca- calcium; Phos- phosphorus; HCO₃- bicarbonate; PTH- parathyroid hormone level; Fe- iron; TIBC- total iron binding capacity; URR- urea reduction ratio; nPCR- nitrogen protein catabolic rate; ‡‡Dialysis Machine Derived Parameters: BP-pre, BP-post, Lowest BP, Weight-pre, Weight-post, Intradialytic Weight Gain, & Average Blood Flow Rate.