Table 1.
Adult cystic fibrosis patient demographics from those with isolated Pneumococcus cultures
| Patient | Age a | Sex | Mutation 1 | Mutation 2 | BMI b | FVC (L) c (% predicted) | FEV 1 (L) d (% predicted) | Pancreatic sufficient | Smoker status | CF Co-morbidities | Chronic pathogens e |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 30 | M | M1101K | M1101K | 21.87 | 1.62 (35) | 0.76 (20) | N | N | N | PA, SA, HI, Bcc |
| 2 | 23 | M | F508del | M1101K | 16.05 | 3.29 (61) | 0.94 (20) | N | N | Liver disease | PA, SA |
| 3 | 30 | F | F508del | P67L | 32.03 | N/A | N/A | Y | Y | N | SA |
| 4 | 28 | M | F508del | F508del | 18.23 | 3.75 (68) | 2.42 (54) | N | N | Sinus | PA, Bcc |
| 5 | 29 | F | F508del | F508del | 15.58 | 2.06 (53) | 1.08 (32) | N | N | CFRD, Sinus | PA |
| 6 | 24 | M | F508del | D110H | 24.38 | 7.57 (140) | 5.98 (128) | Y | Y | N | HI |
| 7 | 24 | M | F508del | F508del | 16.20 | 3.77 (73) | 1.4 (32) | Y | N | Sinus | PA |
| 8 | 30 | M | 3659delC | 394delTT | 18.79 | 3.95 (75) | 1.80 (41) | N | Y | Liver disease | PA |
| 9 | 28 | M | F508del | F508del | 21.20 | 6.1 (117) | 4.3 (100) | N | N | N | PA, SA |
| 10 | 23 | M | F508del | G551D | 20.1 | 5.08 (88) | 3.55 (74) | N | N | Sinus | PA, SA |
| 11 | 30 | F | F508del | Unknown | 19.0 | 1.58 (35) | 1.08 (29) | N | N | CFRD | PA |
| 12 | 18 | M | F508del | G178R | 20.8 | 4.04 (107) | 3.01 (86) | N | Y | Arthropathy, Sinus | SA, HI |
| 13 | 28 | F | F508del | F508del | 19.7 | 2.48 (73) | 1.5 (51) | N | N | N | PA |
| 14 | 40 | F | F508del | F508del | 25.4 | 4.45 (134) | 3.08 (110) | N | Y | CFRD, Arthropathy | PA, HI |
| 15 | 22 | M | F508del | F508del | 21.7 | 4.26 (85) | 2.94 (68) | N | N | Arthropathy | PA, SA |
aAge at time of first isolation of S. pneumoniae.
bBMI: body mass index.
cFVC: forced volume capacity, defined as an average of two values in the year preceding time of pneumococcus isolation.
dFEV1: forced expiratory volume, defined as an average of two values in the year preceding time of pneumococcus isolation.
ePA: P. aeruginosa, SA: S. aureus, HI: Haemophilus influenzae, Bcc: Burkholderia cepacia complex; chronicity as defined by repeated isolation of pathogen on at least 50% of cultures over the prior two years.