Table 2.
Pneumococcus isolates from 1986–2013 in adult cystic fibrosis patients
| I | Patient a | Date of isolation | Capsular serotype b | CFU | Influenza vaccine d | Decreased PFT e | Need for Anti-biotics f | Co-Isolated organisms (CFU) g | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Antibiotic susceptibility c | ||||||||||||
| PEN | LVX | AZM | CLI | |||||||||
| 1 | 1 | 1986-05-21 | N/Ah | 107 | N/A | N/A | N/A | N/A | Y | N | Y | PA non-muc (107), PA muc (105) Bcc (106), HI (105) |
| 2 | 2 | 1994-03-16 | 6A/B | 107 | S | S | S | S | Y | Y | Y | PA non-muc (105), PA muc (107) SA (108) |
| 3 | 3 | 1992-09-18 | N/A | 107 | S | N/A | N/A | N/A | N | N/A | N | SA (108) |
| 4 | 3 | 1992-12-16 | N/A | 108 | S | N/A | N/A | N/A | Y | N/A | N | SA (108), HI (108) |
| 5 | 3 | 1993-03-04 | 22 | 107 | S | S | S | S | N | N | Y | SA (107), HI (108) |
| 6 | 3 | 1993-03-05 | 9A/V | 107 | S | S | S | S | N | N | Y | SA (107), HI (108) |
| 7 | 4 | 1993-03-17 | 6A/B | 107 | S | S | S | S | Y | N | N | PA non-muc (107), PA muc (107), Bcc (105), EC (105) |
| 8 | 5 | 1996-12-04 | 33A/F | 107 | S | S | S | S | Y | N | N | PA non-muc (106), PA muc (107) |
| 9 | 5 | 2009-04-08 | 23A | 106 | S | S | S | S | Y | N | Y | PA muc (105) |
| 10 | 6 | 1990-01-17 | N/A | 107 | S | N/A | N/A | N/A | Y | N | N | CA (107) |
| 11 | 7 | 1993-01-06 | N/A | 107 | S | N/A | N/A | N/A | Y | N | N | PA non-muc (107), PA muc (107) |
| 12 | 8 | 1995-10-18 | 23 F | 107 | S | S | S | S | Y | Y | Y | PA non-muc (107), PA muc (106) |
| 13 | 8 | 1995-11-01 | 23 F | 107 | S | S | S | S | Y | Y | Y | PA non-muc (107), PA muc (106) |
| 14 | 9 | 1996-10-02 | 38 | 107 | R | R | S | Y | Y | N | PA non-muc (106), SA (106), CA (105), Asp (105) | |
| 15 | 10 | 1995-12-20 | 7B/C | 105 | S | S | S | S | Y | Y | N | PA muc (105) |
| 16 | 10 | 1996-07-31 | 14 | 104 | S | S | S | S | Y | N | N | PA muc (106), SA (104) |
| 17 | 10 | 1996-08-28 | 9A/V | 105 | S | R | R | S | Y | N | N | PA muc (107), CA (104) |
| 18 | 11 | 1995-11-22 | 23B | 107 | R | S | S | S | Y | N | Y | PA non-muc (106), PA muc (107), EC (105) |
| 19 | 11 | 1996-02-21 | 23B | 107 | S | S | S | S | Y | N | Y | PA non-muc (107), PA muc (107), EC (106) |
| 20 | 12 | 2001-08-21 | N/A | 107 | S | N/A | N/A | N/A | N | N | Y | OF (107) |
| 21 | 12 | 2003-08-20 | NTi | 106 | S | R | R | S | Y | N | N | N/A |
| 22 | 12 | 2006-07-17 | N/A | 106 | S | N/A | N/A | N/A | Y | N/A | N/A | N/A |
| 23 | 12 | 2006-07-21 | NT | 106 | S | R | S | S | Y | N | N | Cfc (104), HI (106) |
| 24 | 12 | 2009-01-05 | 14 | 105 | S | R | R | S | Y | N | N | HI (106) |
| 25 | 13 | 2004-06-16 | N/A | 107 | S | N/A | N/A | N/A | Y | N | N | PA muc (107) |
| 26 | 14 | 2003-11-26 | N/A | 106 | S | N/A | N/A | N/A | Y | N | N | SA (106), PA non-muc (104), PA muc (104), HI (106) |
| 27 | 15 | 2013-10-21 | NT | 106 | S | R | S | S | N | N | N | PA non-muc (104), PA muc (106), SA (106) |
aRefer to Table 1.
bCapsular serotyping done on recoverable isolates.
cAntibiotic definitions: Penicillin = PEN, Levofloxacin = LVX, Azithromycin = AZM, Clindamycin = CLI, S = Sensitive, R = Resistant
dInfluenza vaccine prior to pneumococcus isolation.
eReduced PFT: pulmonary function tests; as defined by a reduction in reduction in FEV1 by >10% at time of visit compared to baseline FEV1 levels.
fRequirement for antibiotics at time of pneumococcus presentation.
gPA: P. aeruginosa, SA: S. aureus, HI: Haemophilus influenzae, Bcc: Burkholderia cepacia complex, Asp: Aspergillus. sp, EC: E. coli, CA: Candida albicans, Cfc: Citrobacter freundii complex, OF: oropharyngeal flora.
hN/A: Not available for serotyping or antibiotic susceptibility testing.
iNT: non-typeable serotype but with positive cps internal PCR product control.