Figure 2. The landscape of protein expression from human developmental tissues.

(A) The mRNA expression (FPKM) from LCL was computed for gene transcript (>75^th percentile expression of all genes in the genome) and the number of transcripts for each gene in the genome was computed. The red line represents the average number of transcripts in the genome that is above threshold. The circle represents transcript abundance above threshold for each disease (colored by disease). (B) Each immune mediated risk gene set and the proportion of highly (>75^th percentile expression of the genome of all tissue) expressed genes in each tissue (Y-axis). The two developmental periods (fetal and adult) and the tissues are highlighted in different red gradients (X-axis, light to dark red) that correspond to the ratio of genes. Each line represents an immune mediated disease risk gene set and their corresponding ratio of highly expressed genes for a tissue (colored by disease).