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. 2015 May 18;5:10314. doi: 10.1038/srep10314

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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The enrichment analysis of pathways through gene set association was conducted for each gene set. Each node within the network represents a significant gene set belonging to a pathway. The number of edges of a pathway node corresponds to the number of risk genes overlapped with that particular pathway gene set. The size of the node corresponds to the p-value. The mapped green nodes represent overlapping significant pathways between AS (red node) and other immune mediated diseases (blue node). The range of p-values for the overlapping pathways is indicated next to each disease group. The most significant top two pathways that overlap with AS risk genes are displayed below the p-value.