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. 2015 May 18;5:10291. doi: 10.1038/srep10291

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Copyright © 2015, Macmillan Publishers Limited

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Circulating mRNA in predicting response to and outcome of preoperative chemoradiation. (a) The change in circulating levels of CCNL1, FAM84B, and SEPT4 mRNAs between pathological complete responders (pCR) and non-complete responders (non-pCR) measured by quantitative reverse-transcriptase polymerase chain reaction. Data shown as a scatter plot and the intersecting line shows the median value with the interquartile range. (b) Receiver-operating characteristic curve shows the performance of fold-change in FAM84B mRNA expression in predicting the pathological complete response, with the area under curve being 0.73. (c) Kaplan-Meier curves of the disease-free survival stratified by fold-change in FAM84B mRNA expression using a cutoff value of 0.3 (p = 0.15).