Fig. 1.

Hippocampus of young TTR^−/− mice have decreased levels of IGF-IR. Representative images of western blot analysis and quantitative charts of IGF-IR levels in a hippocampus samples of 3 months TTR^+/+ (n = 5) and TTR^−/− (n = 4) mice; b hippocampus samples of 9 months TTR^+/+ (n = 4) and TTR^−/− (n = 5) animals; c hippocampus samples of control (n = 6) and LNP (n = 6)-treated mice. Results are presented as average ± SEM. Error bars represent SEM. *P < 0.05 in a Student’s t test