Table 5. Hemolytic activity (Percent ± SD) of DMs on human erythrocytes.
| Peptide | Hemolytic activity (μg/ml) Percent hemolysis ± SD | ||
|---|---|---|---|
| HC10 | HC50 | Hmax (%) | |
| DM1 | >250 | >250 | 0.5 ± 0.1 |
| DM2 | 114.3 ± 26.1 | >250 | 13.9 ± 2.0 |
| DM3 | 52.7 ± 5.5 | >250 | 39.0 ± 2.5 |
| DM4 | >250 | >250 | 0.6 ± 0.1 |
| DM5 | >250 | >250 | 0.9 ± 0.4 |
| PEN | >4 | >4 | 0.6 ± 0.3 |
HC10 and HC50 were defined as the concentrations of peptide causing 10% and 50% hemolysis on human erythrocytes, respectively.
Hmax was defined as the percentage (%) hemolysis of peptide at the highest concentration tested (all peptides - 250 μg/ml; PEN - 4 μg/ml).