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. 2015 May 18;7:7. doi: 10.3389/fnsyn.2015.00007

Figure 6.

Figure 6

The slow component of the GluA2-lacking AMPAR EPSC is developmentally downregulated. (A) Representative average EPSCs before and after of bath application of PhTx are shown in an interneuron from a neonatal mouse. (B) Representative average EPSCs before and after bath application of PhTx in an interneuron from an older, juvenile mouse. (C) PhTx sensitive currents in neonatal and juvenile mice normalized to total response. Inset view of tail currents. Average kinetics of the slow component differs between neonatal and juvenile age groups. (D) Graph of average inhibition by PhTx in neonatal and juvenile animals. There was no difference in the inhibition of the first peak, but the total integral was inhibited to a greater degree in neonataler cells.