Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 May 18;7:7. doi: 10.3389/fnsyn.2015.00007

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Stincic and Frerking.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

A summary of AMPAR and EAAT localizations for glutamatergic synapses onto SR/SLM interneurons. Synaptic AMPARs can be subdivided into two kinetically distinct forms, one with slow kinetics and the other with fast kinetics; similarly, they can be subdivided according to the presence or absence of GluA2. (A) Among the receptors with fast kinetics, GluA2-containing AMPARs predominate; among those with slow kinetics, GluA2-lacking AMPARs predominate. EAAT1, a glial glutamate transporter, is primarily responsible for the uptake that suppresses glutamate spill-over to activate extrasynaptic AMPARs; these extrasynaptic AMPARs predominantly contain GluA2. EAAT3 is also present, but plays a lesser role in limiting spillover. The question mark denotes uncertainty in the localization of this transporter at this synapse. (B) Over the course of development, AMPARs with slow kinetics are removed from the synapse independent of their GluA2 content. The relative proportion of receptors represents the contribution of each subtype to the overall charge transfer and does not presume to represent the actual population number due to the influence of subtype specific parameters such as conductance.