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. 2015 May 18;5:10129. doi: 10.1038/srep10129

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(a) The half-maximal pharmacodynamic response (PD₅₀) from in vitro experiments was plotted versus the EC₅₀ value from viability assays for the cell lines listed in Supplementary Table S1. (b) The maximum fold change in foci formation in vivo (x-axis) is plotted versus the half-maximal pharmacodynamic response (PD₅₀, blue) or versus the EC₅₀ (red) from viability assays.