Table 4.
Detailed metabolic profile of K+ sparing diuretics.
| K+ sparing diuretic name | Metabolites | Enzymes | References |
|---|---|---|---|
| Amiloride | Not metabolized | [80] | |
| Eplerenone | 21-Hydroxy eplererone | CYP3A4 | [81] |
| 6b-Hydroxy elpererone | CYP3A4 | [81] | |
| 6b, 21-Dihydroxy elpererone | CYP3A4 | [81] | |
| 3a, 6b-Dihydroxy elpererone | CYP3A4 | [81] | |
| 6b, 15a-Dihydroxy elpererone | CYP3A4 | [81] | |
| 3a, 6b, 21-Trihydroxy elpererone | CYP3A4 | [81] | |
| 2a, 3b, 6b-Trihydroxy elpererone | CYP3A4 | [81] | |
| Spironolactone | Spironolactone-thiole | [82] | |
| Spironolactone-dethioacetate | [82] | ||
| Canrenone | [82] | ||
| Thio-methyl-spironolactone | [82] | ||
| Hydroxyl-thiomethyl-spironolactone | [82] | ||
| Triamterene | 4-Hydroxy triamterene | CYP1A2 | [83] |
| 4-Hydroxy-sulfate-triamterene | Sulfotransferases | [83] |