Table 5.
Detailed metabolic profile of loop diuretics.
| Loop diuretic name | Metabolites | Enzymes | References |
|---|---|---|---|
| Bumetanide | Debutylbumetanide | [85] | |
| Alpha-hydroxy bumetanide | [85] | ||
| Bumetanide carboxylic acid | [85] | ||
| Bumetanide glucuronides | UDP-Glucuronosyltransferase | [85] | |
| Ethacrynic acid | Glutathione conjugation | Gloutathione-S-transferases | [86] |
| Mercapturic Acid | [86] | ||
| Furosemide | 4-Chloro-5-sulfamoyl anthranilic acid | [87, 88] | |
| Torasemide | Hydroxylation of the methyl group of the benzyl ring | CYP2C8, CYP2C9 | [89] |
| M1 carboxylic acid | CYP2C8, CYP2C9 | [89] | |
| 4-Hydroxy torasemide | CYP2C8, CYP2C9 | [89] |