Figure 1.

(A) Spontaneous apoptotic rate of neutrophils in the whole blood of FMF patients (FMF; n = 8) and healthy subjects (Cont; n = 8) in culture (media): 0 – basal apoptotic rate; 3 h – spontaneous apoptotic rate of the cells cultured in media (untreated) for 3 h; 24 h – spontaneous apoptotic rate of the cells cultured in media (untreated) for 24 h. Data are represented as the % annexin V+ cells (mean ± SEM). *p < 0.05, **p < 0.01 – significant value. (B,C) Effects following inducers: LPS, TNF-α, MDP, Pam₃CSK4 (CSK4), ATP, colchicine (Col) on the apoptotic rate of circulating neutrophils in the blood of patients with FMF and healthy subjects (CTL) cultured for 3 (B) and 24 h (C). *p < 0.05 vs. untreated cells; ^#p < 0.05, ^##p < 0.01 vs. healthy PMNs. Data are represented as the % annexin-V+ cells (mean ± SEM).