Figure 1.
Electrically evoked sharp wave-ripple complexes (SPW-R) closely resemble spontaneous events. (A,B) Example traces of spontaneous (left) and evoked (right) SPW-R in CA1 (A) and CA3 (B), respectively. Evoked SPW-R show the same features like spontaneous SPW-R in different frequency bands corresponding to the sharp wave (low pass), ripple oscillations (band pass) and multi-unit activity (high pass). (C) Individual SPW-R waveforms (left) were analyzed by principal component analysis (PCA) and their similarity was quantified in the first 10 dimensions of the principal component (PC) space (middle, only two PCs are shown). Red dots indicate individual evoked SPW-R shown on the left panel, gray dots indicate spontaneous SPW-R. A smaller inter-group pair-wise average distance indicates more similar waveforms. To compare evoked and spontaneous events we quantified the overlap of events (right, see Methods).