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. 2015 May 18;6:182. doi: 10.3389/fgene.2015.00182

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Copyright © 2015 Rhein, Hagemeier, Klintschar, Muschler, Bleich and Frieling.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) DNA gel electrophoresis for 3 of the six human subjects analyzed for comparison. Degraded DNA was put in relation to total DNA in the respective lane for normalization. (B) Epigenetic variance of the ALDH2 gene for timepoints investigated in human DNA is stable both between blood and brain as well as in regards to variance of measurements. The mean methylation rate (%) of 10 CpGs of 6 brain regions was calculated for 5 post mortem subjects and is plotted against respective PMI for the two tissues analyzed. All error bars are ±SEM.