FIG. 3.

Binding motif identified to be highly conserved in DNA sequences identified in TCF21 binding target gene promoters. Analysis was done using MEME software with TOMTOM follow up. Approximately 500–800 bp of all direct downstream target gene promoters were aligned and used for analysis. The core sequence for TCF21 binding was found to be CANNTC, which is common for many bHLH factors. A) The 22-bp core sequence for TCF21 binding. B) The reverse complementary sequence for TCF21 binding motif.