Figure 2. Functional Connectivity Differences Between Patients and Controls.

A, The 61 × 61 grid shows the differences in resting blood oxygenation level–dependent correlation between controls and patients for each intrahemispheric regional pair. Differences were obtained by an analysis of variance of z-transformed Pearson correlation values after linear regression of the effects of age, sex, race, and handedness. Regions are ordered based on their network groupings adapted from Yeo et al.²⁶ Diagonal white lines represent network boundaries. B, Manhattan plot showing associated network-wide P values of psychosis-related differences in functional connectivity. The y-axis shows the −log₁₀ P values of 240 within-network regional pairs, and the x-axis shows their network positions. The horizontal red line represents the threshold of P = 1.37 × 10⁻⁵ for Bonferroni-corrected significance; the horizontal blue line represents the threshold of P = 7.8 × 10⁻³ that corresponds to the false discovery rate (q < 0.05). See Figure 1 legend for explanation of abbreviations.