Table 3.

HZ mortality data from included studies

Study (ref)	Country	Period	Age (years)	Age at HZ-related death	Mortality incidence/100 000 (95% CI)	Case fatality rate (%)	Hospital fatality rate (%)	Number
Bilcke 2011 [21]	Belgium	1990-2007	60-70		0.06
			70+		0.63
Gonzalez Chiappe 2010 [27]	France	2000-2007	Overall	96.8% (1360; 170/year) in those aged ≥65 years	0.286 (0.244-0.328)	0.075	2.012	1 405 (176 ± 13/year)
			≥65			4.36 ± 0.20
			45-54		0.031 (0–0.069)	0.007
			55-64		0.072 (0.009-0.135)	0.012
			65-74		0.236 (0.102-0.370)	0.027
			75-84		1.25 (0.90-1.60)	0.127
			85-94		7.24 (5.66-8.82)	0.672
			≥95		19.48 (11.50-27.47)	1.356	HFR: Malignancies: 4.236 (449/10 599) HIV/AIDS: 0.357 (26/7 277)
							Diabetes: 1.654 (94/5 682)
							Blood dyscrasias: 3.907 (82/2 099)
							RA: 1.759 (38/2 160)
							Malnutrition: 6.196 (64/1 033)
							Organ transplant: 0.049 (1/2 023)
Ultsch 2011 [30]	Germany	2007-2008	50-54	73% (n = 48) deaths in ≥80 years	0.02 (0.00-0.10)	0.003		1
			55-59		0.00 NA	0		0
			60-64		0.02 (0.00-0.13)	0.003		1
			65-69		0.06 (0.01-0.17)	0.005		3
			70-74		0.11 (0.04-0.27)	0.010		5
			75-79		0.30 (0.14-0.57)	0.025		9
			80-84		0.54 (0.28-0.94)	0.043		12
			85-89		1.20 (0.67-1.98)	0.096		15
			≥90		3.86 (2.36-5.96)	0.293		20
			Overall		0.21 (0.16-0.26)	0.022		66
van Lier 2010 [31]	Netherlands	2000-2007	≥60	92% deaths occurred in ≥ 75 years	0.59 (estimated with pop ≥60 from Eurostat)			Mean 18 deaths/year (range 13–26)
de Melker 2006 [23]	Netherlands	1996-2002	≥75	97% occurred in ≥60 years	1.92 (estimated with pop ≥75 from Eurostat)			Mean 18 deaths/year (range 13 to 26)
Mesquita 2013 [28]	Portugal	2000-2010	50-59	76.8 years (SD = 13.6)			1.0	17 (total)
			60-69				0.4
			70-79				0.8
			80-89				2.9
			90-99				3.8
Perez-Sola 2011 [29]	Spain	2000-2006						0
Gil 2009 [24]	Spain	1998-2004	50-59		0.3		3.8	156/year (mean)
			60-69		0.6		3.7
			70-79		1.5		4.5
			≥80		3.9		7.1
Gil-Prieto 2011 [26]	Spain	1998-2004	50-59				3.0*/1.1
			60-69				2.7*/1.7
			≥70				5.3*/2.7
			50-59				No comorbidity: 1.1
							Comorbidity: 3.0
							Diabetes: 3.0
							COPD: 4.2
							CVD: 3.7
			60-69				No comorbidity: 1.7
							Comorbidity: 2.7
							Diabetes: 1.9
							COPD: 2.7
							CVD: 3.4
			≥70				No comorbidity: 2.7
							Comorbidity: 5.3
							Diabetes: 5.0
							COPD: 5.0
							CVD: 5.9
Gil-Prieto 2012 [25]	Spain	1997-2008	First diagnosis
			≥50§				2.51§ (1.42-3.61)/	20
			≥50#				1.62# (0.67-2.5)	11
			50-59
			60-69				0/0	0§/0#
			≥70				1.16§ (0–0.76)/0#	2§/0#
							3.61§ (1.97-6.25)/	18§/11#
							2.48# (1.03-3.93)
			All ages					22§/11#
							1.89§ (1.1-1.27)/
							1.22# (1.9-5.0)
			Any diagnosis:
			≥50					117§/70#
			50-59					4§/1#
			60-69					16§/3#
			≥70					97§/66#
Brisson 2003 [22]	England & Wales	1991-2000	45-64$		0.014	0.002	0.612	2$
			≥65$		0.566	0.061	3.190	47
			all ages$$		0.094	0.031	2.722)	49
Edmunds 2001 [2]	England & Wales	1995-1999	≥60		2.0 – 4.0
			50-54			0.009
			55-59			0.009
			60-64			0.027
			65-69			0.027
			70-74			0.035
			75-79			0.092
			80-84			0.487
			≥85			2.018

*in those with diabetes, COPD and cardiovascular; § all; #immuno-competent; $data from national statistics; $$ HES data base.