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. Author manuscript; available in PMC: 2015 May 18.
Published in final edited form as: Dev Biol. 2011 Jul 1;357(1):152–164. doi: 10.1016/j.ydbio.2011.06.041

Figure 3. Adult Adamts5−/− mice have myxomatous pulmonary, aortic and mitral valves.

Figure 3

Movat pentachrome stained sections of adult WT (A, D, G) and Adamts5−/− valves (D, E, H). Increased blue staining in the cusps and leaflets of Adamts5−/− is indicative of proteoglycans (B, E, H), verified as versican by IHC (not shown). Quantification of the thickness of the Adamts5−/− versus WT adult PV (A, B), AV (D, E), and MV (G, H) valves is shown in C (*P< 0.02), F (*P< 0.04), and I (*P<0.04) respectively. PV- n=6 Adamts5−/− ; n= 6, WT; AV- n=6 Adamts5−/− ; n=3 WT; MV- n=5 Adamts5−/− ; n=4 WT. PA-pulmonary artery; Ao-aorta; MV-mitral valve; Lt-left cusp; An-anterior cusp. Black/green bars in (A, B, D, E, G, H) indicate regions of proteoglycan staining in the free edge where measurements were taken. Scale bars: A, B, D, E, G, H = 200 μm.