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. 2014 Jun 17;22(8):1530–1543. doi: 10.1038/mt.2014.86

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Copyright © 2014 American Society of Gene & Cell Therapy

This work is licensed under a Creative Commons Attribution 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/

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Intergene expression correlations and single-cell clustering. (a) Genes are clustered by hierarchical single linkage clustering based on the Euclidean distance between rows of the day 16 matrix. Red squares indicate high intracellular correlation between expression levels of pairs of genes. Four groupings of genes mentioned in the text are highlighted: (A) housekeeping genes; (B) sensory neuron markers; (C) sympathetic markers; (D) neuroectodermal and neural crest markers. (b) The percentage of cells in each of the six clusters of cells (1–6) identified by PAM expressing the given marker gene. (c) The proportion of all cells at each timepoint included in each cluster of cells.