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. Author manuscript; available in PMC: 2015 May 18.
Published in final edited form as: Receptors Clin Investig. 2014;2(1):e485. doi: 10.14800/rci.485

Figure 1. EGFR is activated by intracellular molecules.

Figure 1

Cytohesins enhance EGFR activation by directly interacting with the cytoplasmic domains of dimerized receptors and facilitating conformational rearrangements of these domains. PKP2 activates EGFR by facilitating EGFR dimerization even in the absence of ligand stimulation. SFKs directly phosphorylate limited sites on EGFR. Yes-mediated EGFR phosphorylation occurs on the endosome as well, and requires EGF stimulation and pIgA-pIgR transcytosis.