Table 1.
Group 0: Women without vertebral fractures (n = 73) mean (SD) | Group 1: Women with grade 1 vertebral fractures (n = 96) mean (SD) | Group 2: Women with grade 2 or 3 vertebral fractures (n = 38) mean (SD) | P value | P value 0 vs. 2/3 | P value 0 vs. 1 | P value 1 vs. 2/3 | |
---|---|---|---|---|---|---|---|
Age (years) | 57,57 (5,92) | 60,01 (8,12) | 63,64 (8,59) | <0.001 | <0.001 | 0,11 | 0,04 |
Body mass index (kg/m2) | 31,15 (15,54) | 31,38 (12,85) | 30,25 (5,43) | 0,8996 | 1,00 | 1,00 | 1,00 |
Number of parity | 4,78 (1,8) | 4,71 (2,5) | 5,24 (2,6) | 0,49 | 0,99 | 1,00 | 0,72 |
Years since menopause | 7,60 (6,93) | 9,40 (8,64) | 14,86 (10,83) | <0.001 | <0.001 | 0,55 | 0,004 |
SHBG (ng/ml) | 52,46 (27,11) | 57,87 (28,33) | 58,26 (29,75) | 0,4044 | 0,91 | 0,65 | 1,00 |
β-CTX (ng/ml) | 0,43 (0,24) | 0,43 (0,24) | 0,41 (0,24) | 0,9159 | 1,00 | 1,00 | 1,00 |
PTHi (pg/ml) | 41,14 (36,83) | 39,21 (31,46) | 35,89 (5,82) | 0,7166 | 1,00 | 1,00 | 1,00 |
E2 (pmol/l) | 47,49 (43,83) | 43,42 (51,07) | 41,80 (21,70) | 0,7689 | 1,00 | 1,00 | 1,00 |
FEI (pmol/nmol) | 12,11 (11,50) | 10,64 (18,29) | 9,28 (5,94) | 0,6026 | 0,99 | 1,00 | 1,00 |
S-DHEA (μmol/l) | 2,34 (1,24) | 1,97 (0,98) | 2,08 (1,35) | 0,1138 | 0,78 | 0,12 | 1,00 |
25 (OH)D3 (ng/ml) | 13,20 (9,54) | 12,21 (8,07) | 24,42 (3,96) | 0,1495 | 0,41 | 1,00 | 0,16 |
Osteocalcin (μg/l) | 24,21 (13,95) | 23,83 (12,83) | 23,61 (14,33) | 0,9722 | 1,00 | 1,00 | 1,00 |
Lumbar spine BMD (g/cm2) | 0,97 (0,26) | 0,98 (0,18) | 1,02 (0,15) | 0,4367 | 0,62 | 1,00 | 0,91 |
Lumbar spine T-score | -1,29 (1,20) | -1,40 (1,55) | -1,09 (1,25) | 0,5088 | 1,00 | 1,00 | 0,74 |
Total hip BMD (g/cm2) | 0,93 (0,13) | 0,93 (0,14) | 0,86 (0,42) | 0,2162 | 0,31 | 1,00 | 0,34 |
Total hip BMD T-score | -0,79 (1,11) | -0,78 (1,20) | -0,71 (1,01) | 0,9411 | 1,00 | 1,00 | 1,00 |
Mean ± SD : m (SD) *: <0.05 **: < 0.001. One way analysis of variance+Post hoc test (Bonferroni) BMD bone mineral density, BMI body mass index, E estradiol, FEI free estrogen index, PTH parathormone (PTH) intact; S-DHEA dehydroepiandrosterone sulphate, SHBG sex hormones binding globulin, T testosterone