Table 2.

Type-I error rate of the end-points as measurement error varies.

End-point	Type-I error rate
	No measurement error	Medium measurement error (measurement error standard deviation set to 0.1)	High measurement error (measurement error standard deviation set to 0.25)
Single-arm trials
Disease control rate (DCR) fixed	0.039	0.038	0.043
Response rate (RR) fixed	0.043	0.076	0.295
DCR best observed	0.041	0.043	0.092
RR best observed	0.031	0.034	0.091
Two-arm trials
DCR fixed	0.047	0.047	0.050
RR fixed	0.034	0.035	0.042
RR best observed	0.036	0.035	0.038
PFS	0.048	0.048	0.045
Karrison	0.050	0.049	0.051