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. Author manuscript; available in PMC: 2015 May 18.
Published in final edited form as: Biol Psychiatry. 2013 Mar 7;74(4):265–272. doi: 10.1016/j.biopsych.2013.01.030

Figure 3.

Figure 3

a. Hippocampal correlation: During negative emotion-processing the left hippocampus was the only ROI that significantly correlated with trait anxiety (the strongest predictor of group membership). As trait anxiety increased, the hippocampus signal decreased (negative correlation).

b. Hippocampal coupling: Results from psychophysiological interaction analysis showing regions where adolescents with (ES+) and without (ES−) subsyndromal emotional symptoms displayed a significant difference in hippocampus coupling during negative emotion-processing. Specifically, these included the insula (MNI coordinates −33, −18, −21, cluster size 25 voxels, z-score 3.10), amygdala (MNI coordinates 30, 9, 27, cluster size 13 voxels, z-score 3.01), and inferior frontal gyrus (MNI coordinates −54, 03, 3, cluster size 14 voxels, z-score 2.67). This is indicated by the figure which shows the direction of coupling and effect size.