Table 1.

A list of brain regions that show a significant difference in strength between CAE and controls

Regions with significant differences in weighted connectivity (Bonferroni corrected P-values)
	Region name	Left	Right
(A) CAE increase
Frontal	Anterior cingulate (caudal)	0.0003*	0.0003*
	Anterior cingulate (rostral)	0.015*	>0.5
	Middle frontal gyrus	0.010*	0.392
	Supramarginal	0.076	0.004*
	Lateral orbito-frontal	0.109	0.004*
	Precentral	0.006	0.212
Insula		0.397	0.00005*
Temporal	Superior temporal	0.018*	0.063
	Entorhinal	0.005*	>0.5
	Fusiform	>0.5	0.00007*
(B) CAE decreases
Posterior	Lateral occipital	0.016*	0.058
	Inferior parietal	0.031*	0.075
	Lingual	0.033*	>0.5

All increases were in fronto-temporal regions, all decreases in parieto-occipital regions. Nodes are considered significant if the difference passed a two-tailed P < 0.05 threshold. P-values were Bonferroni corrected for the number of nodes; values passing significance at this threshold are marked with asterisk (^*). We see the caudal anterior cingulate is maximally affected bilaterally. Lateral and medial occipital decreases pass the significance threshold on the left side only, although a general trend toward occipital decrease is observed, see Figure3A. CAE, childhood absence epilepsy.