Table 3.
Baseline demographic and clinical covariates by T2 lesion load
| Variable | Level | T2 lesion load | P-value | ||||
|---|---|---|---|---|---|---|---|
| 0 (n = 77) | 1–2 (n = 106) | 3–8 (n = 1027) | ≥9 (n = 540) | N/A (n = 239) | |||
| Demographics | |||||||
| Sex | Male | 14 | 30 | 306 | 161 | 60 | 0.1581 |
| Female | 63 | 76 | 721 | 379 | 179 | 0.1581 | |
| Age at onset | Mean (SD) | 32.3 (8.6) | 33.7 (9.8) | 32.5 (9.8) | 33.4 (10.4) | 33.3 (10.1) | 0.2262 |
| Clinical | |||||||
| EDSS | Median (IQR) | 1.5 (1, 2) | 1.5 (1, 2) | 1.5 (1, 2) | 1.5 (0, 2) | 1.5 (1, 2) | 0.40293 |
| Treatment | n = 18 (23%) | n = 43 (40.1%) | n = 705 (68.6%) | n = 407 (75.4%) | n = 166 (69.5%) | ||
| Time to first DMT from CIS onset | Median (IQR) | 2.5 (1.2, 3.7) | 0.9 (0.5, 1.5) | 0.8 (0.4, 1.3) | 0.6 (0.3, 1.1) | 0.7 (0.3, 1.0) | 0.00013 |
| Mean (SD) | 3.1 (2.5) | 1.2 (1.1) | 1.1 (1.2) | 0.8 (0.8) | 1.0 (1.2) | ||
| PTT (continuous) | Median (IQR) | 0.5 (0.3, 0.6) | 0.6 (0.3, 0.8) | 0.7 (0.5, 0.8) | 0.7 (0.5, 0.9) | 0.7 (0.4, 0.8) | 0.00033 |
| Mean (SD) | 0.4 (0.2) | 0.5 (0.3) | 0.6 (0.3) | 0.7 (0.3) | 0.6 (0.3) | ||
| Disease classification at treatment start | CIS | 1 (5.5%) | 6 (14.0%) | 124 (17.6%) | 96 (23.6%) | 25 (15.1%) | |
| RRMS | 17 (94.5%) | 37 (86.0%) | 581 (82.4%) | 311 (76.4%) | 141 (84.9%) | ||
1
Pearson's χ2.
2
One-way ANOVA, Bonferroni's post hoc test.
3
Kruskal–Wallis.