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. 2015 Apr 7;2(5):548–558. doi: 10.1002/acn3.195

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© 2015 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Correlation between gray matter volume reduction and decline in Axis 1 score in symptomatic patients. (A) Axial and (B) coronal SPM-t maps showing in red–yellow voxels demonstrating statistically significant correlation between GM volume reduction and decline in 1st SCE-PCA component (Axis 1) score in symptomatic patients (n = 23). Results are shown using false discovery rate q < 0.05 to control for multiple comparisons, and are overlaid on the average of all the anatomical data set registered to the group-specific template. The colorbar range for t-values is 2.5–5. (C) Scatter plot showing correlation of GM partial volume fraction with Axis 1 over an ROI manually drawn in the left angular gyrus: Spearman-rank correlation coefficient = 0.602, P = 0.004. SCE, short cognitive examination; PCA, principal components analysis; GM, gray matter; ROI, region of interest.