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A partial list of mechanisms implicated in acquired resistance to EGFR TKI
| Secondary Mutations | Activation of alternate pathways | Other pathways |
|---|---|---|
| EGFR T790M (24, 25) | HER2 amplification (58) | Activation of PD-1 (30) |
| EGFR D761Y (39) | MET amplification (26, 27) | Epithelial to mesenchymal transition (29, 33, 59) |
| EGFR T854A (40) | mTORC1 (60) | Small Cell Transformation (61, 62) |
| BRAF V600E (63) | AXL (64) | |
| NRAS mutation (65) | IGF1-R (66, 67) | |
| FGFR activation (68, 69) |
