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. Author manuscript; available in PMC: 2015 May 18.
Published in final edited form as: Chem Soc Rev. 2011 Jun 14;40(12):5707–5717. doi: 10.1039/c1cs15076f

Figure 2.

Figure 2

Approaches to DNA-recorded library synthesis. A) Neri and co-workers synthesized a 4,000-membered DNA-encoded library using a bicyclic Diels-Alder-formed scaffold and DNA-tag synthesis using primer extension. A similar 4,000-membered DNA-encoded library was also synthesized using amide-bond-formation chemistry. B) Researchers at Praecis Pharmaceuticals assembled a 7-million-membered DNA-encoded library using alternating cycles of enzymatic DNA ligation and chemical synthesis on a triazine scaffold.