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. Author manuscript; available in PMC: 2015 May 18.
Published in final edited form as: Chem Soc Rev. 2011 Jun 14;40(12):5707–5717. doi: 10.1039/c1cs15076f

Table 1.

Bioactive synthetic small molecules discovered from DNA-encoded chemical libraries and in vitro selection.

Target Structure Kd / IC50
Crk-SH3 graphic file with name nihms687145t1.jpg 16 µM
HSA graphic file with name nihms687145t2.jpg 3.2 µM
MMP3 graphic file with name nihms687145t3.jpg 9.9 µM
Bcl-xL graphic file with name nihms687145t4.jpg 930 nM
TNF graphic file with name nihms687145t5.jpg 15 µM
CA IX graphic file with name nihms687145t6.jpg 260 nM
Aurora A graphic file with name nihms687145t7.jpg 270 nM
p38 MAPK graphic file with name nihms687145t8.jpg 7 nM
Src graphic file with name nihms687145t9.jpg 680 nM / 960 nM
p38α-MK2 graphic file with name nihms687145t10.jpg 3.4 µM