Table 3.
Univariate and multivariate analyses of different prognostic factors in 1148 patients with gastric carcinoma for disease-free survival
| Variable | Univariate analysis* | Multivariate analysis | |||
|---|---|---|---|---|---|
| All cases | HR (95% CI) | P value | HR (95% CI) | P value | |
| Sex | 0.936 | ||||
| Female | 354 | Reference | |||
| Male | 794 | 1.007 (0.851-1.192) | |||
| Age at diagnosis (years) | 0.359 | ||||
| ≤59 | 574 | Reference | |||
| >59 | 574 | 1.075 (0.921-1.255) | |||
| CEA† | 0.068 | ||||
| Normal | 791 | Reference | |||
| Elevated | 157 | 1.227 (0.985-1.528) | |||
| CA19-9‡ | <0.0001 | 1.145 (0.929-1.411) | 0.204 | ||
| Normal | 707 | Reference | |||
| Elevated | 195 | 1.499 (1.221-1.840) | |||
| Size (diameter), cm | <0.0001 | 1.334 (1.111-1.602) | 0.002 | ||
| ≤5 | 697 | Reference | |||
| >5 | 451 | 1.643 (1.407-1.919) | |||
| Lauren classification | 0.001 | 0.821 (0.619-1.090) | 0.173 | ||
| Diffuse | 585 | Reference | |||
| Mixed/ Intestinal | 563 | 0.768 (0.657-0.897) | |||
| Differentiation | <0.0001 | 1.085 (0.801-1.470) | 0.598 | ||
| Well/moderate | 435 | Reference | |||
| Poor/undifferentiated | 713 | 1.374 (1.166-1.618) | |||
| Gastric wall invasion | <0.0001 | 2.164 (1.416-3.308) | <0.0001 | ||
| T1/T2 | 150 | Reference | |||
| T3/T4 | 998 | 4.450 (3.083-6.424) | |||
| Nodal metastasis | <0.0001 | 0.788 (0.571-1.088) | 0.148 | ||
| N0 | 377 | Reference | |||
| N1-N3 | 771 | 2.545 (2.106-3.075) | |||
| Distant metastasis | <0.0001 | 2.259 (1.785-2.858) | <0.0001 | ||
| M0 | 1003 | Reference | |||
| M1 | 145 | 3.544 (2.906-4.321) | |||
| TNM stage | <0.0001 | 2.234 (1.596-3.127) | <0.0001 | ||
| I/II | 486 | Reference | |||
| III/ IV | 662 | 3.062 (2.570-3.649) | |||
| Lymphovascular invasion | <0.0001 | 1.393 (1.150-1.688) | 0.001 | ||
| Absent | 744 | Reference | |||
| Present | 404 | 2.046 (1.749-2.394) | |||
*Cox regression model; †Preoperative serum CEA was measured in 948 patients; ‡Preoperative serum CA19-9 was measured in 902 patients; HR indicates hazards ratio; CI indicates confidence interval; CEA indicates carcinoembryonic antigen; CA19-9 indicates carbohydrate antigen 19-9.