Table 1.

Inclusion and Exclusion Criteria

	Inclusion Criteria	Exclusion Criteria
Patients	• At least 18 years of age • English speaking • Right handed • Rating of at least “1” on SYM-Q, question #1 • Unpleasant pain localised to pelvis • IC symptoms present for the majority of the time during any 3 months in the past 6 months • IC symptoms present for the majority of the time in the most recent 3 months	• On-going neurological disease or disorder affecting the bladder or bowel fistula • A history of cystitis caused by tuberculosis, radiation therapy or Cytoxan/cyclophosphamide therapy • Augmentation cystoplasty or cystectomy • Active autoimmune or infectious disorder (e.g. Crohn's Disease or Lupus) • A history of cancer (with the exception of skin cancer) • Current major psychiatric disorder or other psychiatric or medical issues that would interfere with study participation • Severe cardiac, pulmonary, renal, or hepatic disease • CNS disease, including structural brain abnormalities (e.g. neoplasms, subarachnoid cysts) and cerebrovascular disease • Ongoing infectious disease (e.g. abcess • History of other neurological disease including stroke or seizure disorders • Claustrophobia • Vision/hearing impairments • Any metal implants
Healthy Controls	• At least 18 years of age • English speaking • Right handed • Rating of “0” on SYM-Q, question #1 • No chronic pain in pelvic or bladder region, and chronic pain in no more than one o than body region • No urological symptoms that have been evaluated, but are still present