Table 4.

Grade 3 or 4 adverse events of interest for oxaliplatin therapy

	Leucovorin and fluorouracil with or without oxaliplatin (n=3829)	Capecitabine with or without oxaliplatin (n=1927)
All adverse events	1731 (45%)	690 (36%)
Neutropenia	908 (24%)	91 (5%)
Diarrhoea	475 (12%)	296 (15%)
Neuropathy	295 (8%)	113 (6%)
Vomiting or nausea	203 (5%)	141 (7%)
Stomatitis, all	135 (4%)	6 (<1%)
Hand–foot syndrome	30 (<1%)	228 (12%)
Febrile neutropenia	80 (2%)	7 (<1%)
Neutropenic fever or sepsis	20 (<1%)	2 (<1%)

Data are n (%). The denominators are the numbers of patients who actually received the treatment regimens considered in this comparison.