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. Author manuscript; available in PMC: 2015 May 18.
Published in final edited form as: Cell. 2005 Dec 16;123(6):1051–1063. doi: 10.1016/j.cell.2005.09.035

Figure 2. X Chromosome Pairing Is Defective in him-8 Mutants.

Figure 2

(A) Diagram of a hermaphrodite gonad, indicating the five zones in which the pairing of FISH signals was scored.

(B) Genomic localizations of the three FISH probes used to quantify homolog pairing.

(C) Graphs indicating the fraction of paired FISH signals in each zone for wild-type (N2), him-8(mn353), and him-8(me4) hermaphrodites. Three probes were scored independently: one from the left end of X chromosome (red), one from the right end of X chromosome (green), and the 5S rDNA, which marks the right arm of chromosome V (blue). In both him-8 alleles, pairing of the X chromosome probes did not rise above the baseline levels observed in the premeiotic region (zone 1), whereas Chromosome V association rates and dynamics were very similar to what we observed in wild-type hermaphrodites.