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. Author manuscript; available in PMC: 2015 May 18.
Published in final edited form as: Cell. 2005 Dec 16;123(6):1051–1063. doi: 10.1016/j.cell.2005.09.035

Figure 6. HIM-8 Foci Associate with Nuclear-Envelope Components in Both Wild-Type and him-8(me4) Animals.

Figure 6

(A and B) Pachytene nuclei were stained with antibodies against HIM-8 (yellow) and anti-LMN-1 (red), which marks the nuclear lamina, or nuclear envelope. All scale bars represent 5 µm. See Figure S1 for an optical section through a similar data set, where nuclear-envelope association is somewhat more evident.

(C) A possible role for nuclear-envelope association of meiotic chromosomes is the reduction of homology search from a 3D to a 2D problem. As discussed in the text, our analysis of the him-8(me4) mutant indicates that the requirement for HIM-8 is likely to extend beyond such a role.