Skip to main content
PMC home page
Infection and Immunity logoLink to Infection and Immunity
. 1979 Aug;25(2):565–568. doi: 10.1128/iai.25.2.565-568.1979

Depression of bovine monocyte chemotactic responses by bovine viral diarrhea virus.

A T Ketelsen, D W Johnson, C C Muscoplat
PMCID: PMC443581  PMID: 226479

Abstract

Incubation of bovine peripheral blood monocytes with bovine viral diarrhea virus (either Singer or NY-1 strain) caused a consistent, statistically significant decrease in their random locomotion (no chemoattractant) and chemotaxis towards a chemotactic lymphokine. Chemotaxis was determined by a modification of the Boyden method. Incubation of bovine viral diarrhea virus with mononuclear cells depressed chemotaxis by a mean of 56% (P less than 0.0005). Heat-killed virus had no effect on monocyte motility. Data suggest that bovine viral diarrhea virus can rapidly suppress monocyte functions in vitro, but by unknown mechanisms, not by killing cells.

Full text

PDF
566

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOYDEN S. The chemotactic effect of mixtures of antibody and antigen on polymorphonuclear leucocytes. J Exp Med. 1962 Mar 1;115:453–466. doi: 10.1084/jem.115.3.453. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Campbell P. B. An improved method for the in vitro evaluation of monocyte leukotaxis. J Lab Clin Med. 1977 Aug;90(2):381–388. [PubMed] [Google Scholar]
  3. Cohn Z. A. Macrophage physiology. Fed Proc. 1975 Jul;34(8):1725–1729. [PubMed] [Google Scholar]
  4. Dannenberg A. M., Jr Macrophages in inflammation and infection. N Engl J Med. 1975 Sep 4;293(10):489–493. doi: 10.1056/NEJM197509042931010. [DOI] [PubMed] [Google Scholar]
  5. Johnson D. W., Muscoplat C. C. Immunologic abnormalities in calves with chronic bovine viral diarrhea. Am J Vet Res. 1973 Sep;34(9):1139–1141. [PubMed] [Google Scholar]
  6. Keller H. U., Borel J. F., Wilkinson P. C., Hess M. W., Cottier H. Re-assessment of Boyden's technique for measuring chemotaxis. J Immunol Methods. 1972 Jan;1(2):165–168. doi: 10.1016/0022-1759(72)90043-9. [DOI] [PubMed] [Google Scholar]
  7. Kleinerman E. S., Daniels C. A., Polisson R. P., Snyderman R. Effect of virus infection on the inflammatory response. Depression of macrophage accumulation in influenza-infected mice. Am J Pathol. 1976 Nov;85(2):373–382. [PMC free article] [PubMed] [Google Scholar]
  8. Kleinerman E. S., Snyderman R., Daniels C. A. Depressed monocyte chemotaxis during acute influenza infection. Lancet. 1975 Nov 29;2(7944):1063–1066. doi: 10.1016/s0140-6736(75)90432-8. [DOI] [PubMed] [Google Scholar]
  9. Kleinerman E. S., Snyderman R., Daniels C. A. Depression of human monocyte chemotaxis by herpes simplex and influenza viruses. J Immunol. 1974 Nov;113(5):1562–1567. [PubMed] [Google Scholar]
  10. Lambert G., Fernelius A. L., Cheville N. F. Experimental bovine viral diarrhea in neonatal calves. J Am Vet Med Assoc. 1969 Jan 15;154(2):181–189. [PubMed] [Google Scholar]
  11. Muscoplat C. C., Johnson D. W., Stevens J. B. Abnormalities of in vitro lymphocyte responses during bovine viral diarrhea virus infection. Am J Vet Res. 1973 Jun;34(6):753–755. [PubMed] [Google Scholar]
  12. Muscoplat C. C., Johnson D. W., Teuscher E. Surface immunoglobulin of circulating lymphocytes in chronic bovine diarrhea: abnormalities in cell populations and cell function. Am J Vet Res. 1973 Aug;34(8):1101–1104. [PubMed] [Google Scholar]
  13. Notkins A. L., Mergenhagen S. E., Howard R. J. Effect of virus infections on the function of the immune system. Annu Rev Microbiol. 1970;24:525–538. doi: 10.1146/annurev.mi.24.100170.002521. [DOI] [PubMed] [Google Scholar]
  14. Rossi C. R., Kiesel G. K. Susceptibility of bovine macrophage and tracheal-ring cultures to bovine viruses. Am J Vet Res. 1977 Nov;38(11):1705–1708. [PubMed] [Google Scholar]
  15. Truitt R. L., Schechmeister I. L. The replication of bovine viral diarrhea-mucosal disease virus in bovine leukocytes in vitro. Arch Gesamte Virusforsch. 1973;42(1):78–87. doi: 10.1007/BF01250509. [DOI] [PubMed] [Google Scholar]
  16. Virelizier J. L. Mechanisms of immunodepression induced by viruses: possible role of infected macrophages. Biomedicine. 1975 Jul;22(4):255–261. [PubMed] [Google Scholar]

Articles from Infection and Immunity are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES