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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Surg Oncol Clin N Am. 2015 Apr 20;24(3):397–407. doi: 10.1016/j.soc.2015.03.002

Figure 2. CDKN2A gene products and p53 regulation.

Figure 2

CDKN2A codes for alternatively spliced p14ARF and p16INK4a genes. The p14 protein inhibits MDM2, which ubiquitinates p53. Both p21, induced by p53, and p16 inhibit cyclins that promote cell cycle progression through phosphorylation of retinoblastoma protein (Rb). Rb feeds back to inhibit p16 production.