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Approaches to target miRNAs. Lentiviral delivery of expression vectors for miRNA over-expression or miRNA sponges and inhibitors that can block endogenous miRNA function. Synthetic miRNA mimics can be delivered into cells using nanoparticles or exosomes (89, 90). Nanoparticle and exosomal delivery can also be used for locked nucleic acids or antagomirs that bind and inhibit miRNAs. Diagrams are not drawn to scale.
