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. 2015 May 15;15:409. doi: 10.1186/s12885-015-1380-0

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© Bose et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Association between nuclear fractal dimension (nFD) and features of the tumor microenvironment. (A) Representative DAPI-stained images of TMA cores with high and low nFD (upper panels) and images of the same cores stained for Ki67 (lower panels). (B) Box and whisker plot showing the association between nFD and tumor proliferation. (C) Representative DAPI-stained images of TMA cores with high and low nFD (upper panels) and H & E-stained images of cores from the same patient that were used for assessing lymphocytic infiltration (LI; lower panels). (D) Box and whisker plot showing the association between nFD and LI.