Table 4.
Prevalence of mutations Plasmodium falciparum dihydrofolate reductase ( dhfr ) and dihydropteroate synthase ( dhps ) mutations associated with resistance to sulphadoxine-pyrimethamine detected at day 0
| Mutation | Mutant (n)/Total (N) | Per cent mutant |
|---|---|---|
| dhfr N51I | 209/212 | 99% |
| dhfr C59R | 210/214 | 98% |
| dhfr S108N | 211/214 | 99% |
| dhfr I164L | 2/211 | 1% |
| dhps A437G | 219/225 | 97% |
| dhps K540E | 201/204 | 99% |
| dhps A581G | 4/204 | 2% |
| dhps A613T/S | 2/180 | 1% |
| Double* | 187/193 | 97% |
| Triple* | 196/202 | 97% |
| Quintuple* | 172/182 | 95% |
*Double mutant = Pfdhps mutations A437G and G540E; Triple mutant = Pfdhfr mutations N51I, C59R and S108N; Quintuple mutant = Pfdhfr mutations N51I, C59R, S108N and Pfdhps mutations A437G and K540E.